Frontiers in Ovarian Cancer Science by Hidetaka Katabuchi

Author:Hidetaka Katabuchi
Language: eng
Format: epub
Publisher: Springer Singapore, Singapore

Keywords

Granulosa cell tumorGerm cell tumorFertility-sparing surgeryBEP

10.1 Introduction

Malignant non-epithelial ovarian tumors are relatively rare, but account for approximately 10% of ovarian malignancies. Although there are few reliable clinical trials on the treatment of these tumors, surgical procedures and appropriate chemotherapy regimens have now been established. Each of these tumors has characteristic clinical features that are helpful for proper preoperative diagnosis. In the latest World Health Organization (WHO) classification guidelines for ovarian cancer [1], non-epithelial tumors encompass a large variety of types, including mesenchymal tumors (low- and high-grade endometrioid stromal tumors), mixed epithelial and stromal tumors (adenosarcomas and carcinosarcomas), pure stromal tumors (e.g., fibromas and thecomas), pure sex cord-stromal tumors (SCSTs, e.g., adult granulosa cell tumors or AGCTs and juvenile granulosa cell tumors or JGCTs), mixed SCSTs (e.g., Sertoli-Leydig cell tumors), and germ cell tumors (see Table 6.1 in Chap. 6). Considering relatively high prevalence of SCSTs and malignant ovarian germ cell tumors (MOGCTs) in malignant ovarian tumors, this chapter focuses on the management strategies for these tumors, with a discussion on the molecular aspects of each.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.